XBI · State Street

State Street SPDR S&P Biotech ETF

See how 149 reported holdings combine into this ETF’s P/E and P/S. Market value, signed ordinary earnings and revenue are added before each ratio is calculated.

Holdings dated 21 August 2026Price US$154.43 as of 2 October 2026Coverage limitations apply

Core valuation

Trailing P/E-16.21×98.33% of 99.88% disclosed weight

Latest-quarter run-rate P/E-15.11×99.30% of 99.88% disclosed weight

Trailing P/S7.99×68.59% of 99.88% disclosed weight

Latest-quarter run-rate P/S7.44×68.40% of 99.88% disclosed weight

Coverage is the share of positive eligible-equity holding value represented in each metric. The published holdings account for 99.88% of fund weight. The reliability standard requires at least 90.00% disclosed fund weight and metric coverage, with no individual uncovered holding above 1.00%.

Largest reported holdings

Largest reported ETF holdings with weights and trailing valuation ratios
Holding	Weight	Trailing P/E	Trailing P/S
MRNAMODERNA INC	2.85%	-23.94×	33.86×
TWSTTWIST BIOSCIENCE CORP	1.94%	-86.25×	27.31×
ORKAORUKA THERAPEUTICS INC	1.52%	-41.56×	Unavailable
APGEAPOGEE THERAPEUTICS INC	1.47%	-34.62×	Unavailable
PRAXPRAXIS PRECISION MEDICINES I	1.41%	-23.62×	Unavailable
HALOHALOZYME THERAPEUTICS INC	1.38%	29.35×	7.30×
NTRANATERA INC	1.38%	-306.11×	21.75×
KYMRKYMERA THERAPEUTICS INC	1.38%	-30.56×	87.21×
PTGXPROTAGONIST THERAPEUTICS INC	1.32%	108.63×	31.94×
DNTHDIANTHUS THERAPEUTICS INC	1.31%	-25.70×	2426.39×

Top 10 of 149 reported holdings. * A holding uses its latest full-year result only when both trailing and latest-quarter inputs are unavailable; open the stock for the exact year end.

Most similar funds

Ranked by shared weight across matching disclosed company holdings and explicitly reported same-currency cash.

IBB · iShares Biotechnology ETF41.42% holdings overlap · US market
FTXH · First Trust Nasdaq Pharmaceuticals ETF25.12% holdings overlap · Nasdaq
PTH · Invesco Dorsey Wright Healthcare Momentum ETF24.84% holdings overlap · US market
HELX · Franklin Genomic Advancements ETF22.03% holdings overlap · Cboe BZX
BMED · iShares Health Innovation Active ETF20.78% holdings overlap · NYSE Arca

Sources and limitations

Holdings are sourced from State Street and company financial inputs retain primary-source links. Monetary values are normalised to USD. Corporate actions, reporting lags, unmapped securities and cash can create differences from provider figures.

Open official holdings source

Research holdings date: 21 August 2026. Informational research, not investment advice.