XBI · State Street

State Street SPDR S&P Biotech ETF

See how 149 reported holdings combine into this ETF’s P/E and P/S. Market value, signed ordinary earnings and revenue are added before each ratio is calculated.

Holdings dated 21 August 2026Price US$163.66 as of 24 August 2026Coverage limitations apply

Core valuation

Trailing P/E-18.01×93.70% of 99.88% disclosed weight
Latest-quarter run-rate P/E-13.67×96.78% of 99.88% disclosed weight
Trailing P/S7.87×67.08% of 99.88% disclosed weight
Latest-quarter run-rate P/S7.71×66.90% of 99.88% disclosed weight

Coverage is the share of positive eligible-equity holding value represented in each metric. The published holdings account for 99.88% of fund weight. The reliability standard requires at least 90.00% disclosed fund weight and metric coverage, with no individual uncovered holding above 1.00%.

Largest reported holdings

HoldingWeightTrailing P/ETrailing P/S
MRNAMODERNA INC2.85%-18.03×25.88×
TWSTTWIST BIOSCIENCE CORP1.94%-111.55×22.14×
ORKAORUKA THERAPEUTICS INC1.52%-56.01×Unavailable
APGEAPOGEE THERAPEUTICS INC1.47%-34.19×Unavailable
PRAXPRAXIS PRECISION MEDICINES I1.41%-32.10×Unavailable
HALOHALOZYME THERAPEUTICS INC1.38%36.78×8.51×
NTRANATERA INC1.38%-210.11×19.01×
KYMRKYMERA THERAPEUTICS INC1.38%-31.28×191.44×
PTGXPROTAGONIST THERAPEUTICS INC1.32%-86.52×134.00×
DNTHDIANTHUS THERAPEUTICS INC1.31%-34.97×2983.01×

Top 10 of 149 reported holdings. * A holding uses its latest full-year result only when both trailing and latest-quarter inputs are unavailable; open the stock for the exact year end.

Most similar funds

Ranked by shared weight across matching disclosed company holdings and explicitly reported same-currency cash.

  1. IBB · iShares Biotechnology ETF41.42% holdings overlap · US market
  2. PTH · Invesco Dorsey Wright Healthcare Momentum ETF24.84% holdings overlap · US market
  3. BMED · iShares Health Innovation Active ETF20.78% holdings overlap · NYSE Arca
  4. IBBQ · Invesco Nasdaq Biotechnology ETF20.26% holdings overlap · US market
  5. PBE · Invesco Biotechnology & Genome ETF20.26% holdings overlap · US market

Sources and limitations

Holdings are sourced from State Street and company financial inputs retain primary-source links. Monetary values are normalised to USD. Corporate actions, reporting lags, unmapped securities and cash can create differences from provider figures.

Open official holdings source

Research holdings date: 21 August 2026. Informational research, not investment advice.

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ratio/fox calculates each ETF’s real P/E and P/S as if it was one single company.

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